Conditioned immunosuppression of lipopolysaccharide-induced antibody response of orally immunized mice

被引：4
|
作者：
Morato, EF
GerbaseDeLima, M
Gorczynski, RM
机构：
[1] UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT PEDIAT,SAO PAULO,BRAZIL
[2] UNIV TORONTO,DEPT SURG & IMMUNOL,TORONTO,ON,CANADA
来源：
BRAIN BEHAVIOR AND IMMUNITY | 1997年 / 11卷 / 02期
关键词：
D O I：
10.1006/brbi.1997.0488
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
BALB/C mice previously conditioned in a paired regimen in which cycophosphamide was given in association with a novel taste in the drinking water (saccharin, SAC) subsequently received LPS (1mg/mouse) by oral gavage. Subgroups of mice were reexposed to SAC or water respectively, and anti-LPS antibody production measured 6 days later using an ELISA/ELISPOT assay. Our data show that the immune response to this T-independent antigen, administered orally, is amenable to conditioned immunosuppression in this model system. (C) 1997 Academic Press.
引用
收藏
页码：133 / 139
页数：7
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