Synthesis of (-)-TAN1251A using 4-hydroxy-L-proline as a chiral source

被引：23

作者：

Nagumo, S ^{[1
]}

Matoba, A ^{[1
]}

Ishii, Y ^{[1
]}

Yamaguchi, S ^{[1
]}

Akutsu, N ^{[1
]}

Nishijima, H ^{[1
]}

Nishida, A ^{[1
]}

Kawahara, N ^{[1
]}

机构：

[1] Hokkaido Coll Pharm, Otaru, Hokkaido 0470264, Japan

来源：

TETRAHEDRON | 2002年 / 58卷 / 49期

关键词：

(-)-TAN1251A; anti-muscarinic activity; synthesis 1-azaspiro[4.5]decane; trans-4-hydroxy-L-proline;

D O I：

10.1016/S0040-4020(02)01292-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthetic route of (-)-TAN1251A possessing an antimuscarinic activity was developed on the basis of alkylation of a trans-4-hydroxy-L-proline derivative and the subsequent construction of an azaspiro ring as key steps. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：9871 / 9877

页数：7

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