Glycosylation of Tetraspanin Tspan-1 at Four Distinct Sites Promotes Its Transition Through the Endoplasmic Reticulum

被引：16

作者：

Scholz, Claus-Juergen ^{[2
]}

Sauer, Georg

Deissler, Helmut ^{[1
]}

机构：

[1] Univ Ulm, Sch Med, Dept Obstet & Gynaecol, D-89075 Ulm, Germany

[2] Univ Wurzburg, IZKF Lab Microarray Applicat, D-97070 Wurzburg, Germany

来源：

PROTEIN AND PEPTIDE LETTERS | 2009年 / 16卷 / 10期

关键词：

Tetraspanins; glycosylation; ovarian carcinoma cells; EGFP fusion proteins; DIFFERENTIALLY EXPRESSED GENES; MOLECULAR MARKERS; BREAST-CANCER; IDENTIFICATION; ANTIGEN; PROTEIN; PROFILES; ADENOCARCINOMA; SUPERFAMILY; PROGRESSION;

D O I：

10.2174/092986609789071234

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We showed that Tspan-1, a tetraspanin overexpressed in many human cancers, harbours oligosaccharides at all four potential N-glycosylation sites. Its most abundant form contained only mannose-rich sugar chains but two distinct glycosylation sites could also contain complex carbohydrates. Glycosylation seemed to be required for correct folding and subsequent transition through the endoplasmic reticulum.

引用

页码：1244 / 1248

页数：5

共 28 条

[21] Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress
Li, Jianjun
Wang, Delin
Liu, Junnan
Qin, Yunlang
Huang, Liangliang
Zeng, Qiangfeng
Xiao, Maolin
Hu, Jie
Yang, Qixin
He, Jiang
Mai, Li
Li, Ying
Liu, Wujiang
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2017, 49 (03) : 254 - 261
[22] Four distinct cyclin-dependent kinases phosphorylate histone H1 at all of its growth-related phosphorylation sites
Swank, RA
Thng, JPH
Guo, XW
Valdez, J
Bradbury, EM
Gurley, LR
BIOCHEMISTRY, 1997, 36 (45) : 13761 - 13768
[23] The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence
Zhang, Yiguo
Kobayashi, Akira
Yamamoto, Masayuki
Hayes, John D.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (05) : 3195 - 3210
[24] Treponema pallidum lipoprotein Tp0768 promotes the migration and adhesion of THP-1 cells to vascular endothelial cells through stress of the endoplasmic reticulum and the NF-κB/HIF-1α pathway
Zhou, Xiangping
Tang, Yun
Cao, Ting
Ning, Lichang
Li, Yumeng
Xie, Xiaoping
Hu, Yibao
He, Bisha
Peng, Binfeng
Liu, Shuangquan
MOLECULAR MICROBIOLOGY, 2023, 119 (01) : 86 - 100
[25] The Wheat NLR Protein PM3b Localises to Endoplasmic Reticulum-Plasma Membrane Contact Sites and Interacts With AVRPM3b2/c2 Through Its LRR Domain
Isaksson, Jonatan
Kunz, Lukas
Fluckiger, Simon
Widrig, Victoria
Keller, Beat
MOLECULAR PLANT PATHOLOGY, 2025, 26 (02)
[26] Circular RNA HIPK2 Promotes A1 Astrocyte Activation after Spinal Cord Injury through Autophagy and Endoplasmic Reticulum Stress by Modulating miR-124-3p-Mediated Smad2 Repression
Yang, Jin
Dong, Junjie
Li, Haotian
Gong, Zhiqiang
Wang, Bing
Du, Kaili
Zhang, Chunqiang
Bi, Hangchuan
Wang, Junfei
Tian, Xinpeng
Chen, Lingqiang
ACS OMEGA, 2023, 9 (01): : 781 - 797
[27] TORC2-Dependent Ypk1-Mediated Phosphorylation of Lam2/Ltc4 Disrupts Its Association with the β-Propeller Protein Laf1 at Endoplasmic Reticulum-Plasma Membrane Contact Sites in the Yeast Saccharomyces cerevisiae
Topolska, Magdalena
Roelants, Francoise M.
Si, Edward P.
Thorner, Jeremy
BIOMOLECULES, 2020, 10 (12) : 1 - 23
[28] ANALYSIS OF THE BINDING-SITES OF GD-3+ ON CA2+-TRANSPORTING ATPASE OF THE SARCOPLASMIC-RETICULUM THROUGH ITS EFFECTS ON FLUORESCENCE OF TRYPTOPHAN RESIDUES AND A COVALENTLY ATTACHED FLUORESCENT-PROBE N-(1-ANILINONAPHTHYL-4)MALEIMIDE
IMAMURA, Y
KAWAKITA, M
JOURNAL OF BIOCHEMISTRY, 1991, 110 (02): : 214 - 219

← 1 2 3 →