Treating allergic conjunctivitis using in situ polyelectrolyte gelling systems

被引：4
|
作者：
Kao, Huei-Jen
Lo, Yu-Li
Vong, Wen-Jong
Lin, Yiu-Jiuan
Lin, Hong-Ru [1 ]
机构：
[1] So Taiwan Univ Technol, Dept Chem Engn, Tainan 710, Taiwan
[2] Chung Hwa Coll Med Technol, Dept Nursing, Tainan 717, Taiwan
[3] Chia Nan Univ Pharm & Sci, Dept Appl Chem, Tainan 717, Taiwan
[4] Natl Univ Tainan, Dept Biol Sci & Technol, Tainan 700, Taiwan
[5] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan 717, Taiwan
来源：
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2006年 / 17卷 / 10期
关键词：
ophthalmic drug delivery; in situ gelling vehicle; phase-transition system; polyelectrolyte solutions; allergic conjunctivitis;
D O I：
10.1163/156856206778530740
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We prepared 0.3% Carbopol/15.5% Pluronic and 0.1% Alginate/15.5% Pluronic solutions as the in situ gelling vehicles for ophthalmic drug delivery of cromolyn. The flow properties, in vitro release and in vivo pharmacological response of these polyelectrolyte solutions and of commercial eye drops were evaluated and compared. The polyelectrolyte solutions were free-flowing at pH 4.0 and 25 degrees C, and they turned to strong gets at pH 7.4 and 37 degrees C due to the in situ phase transition. The in vitro release and in vivo pharmacological response indicated that both vehicles retained cromolyn better than the commercial eye drops. The results demonstrated that both systems are usable as in situ gelling vehicles to increase ocular therapeutic efficacy in treating allergic conjunctivitis.
引用
收藏
页码：1191 / 1205
页数：15
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