Potential Use of Cyclodextrins as Drug Carriers and Active Pharmaceutical Ingredients

被引：51

作者：

Arima, Hidetoshi ^{[1
,2
]}

Motoyama, Keiichi ^{[1
]}

Higashi, Taishi ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 5-1 Oehonmachi, Kumamoto 8620973, Japan

[2] Kumamoto Univ, HIGO Hlth Life Sci Interdisciplinary & Glocal Ori, Program Leading Grad Sch, Chuo Ku, 5-1 Oehonmachi, Kumamoto 8620973, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2017年 / 65卷 / 04期

关键词：

cyclodextrin (CyD); drug delivery system (DDS); active pharmaceutical ingredient; non-viral vector; supramolecule; METHYL-BETA-CYCLODEXTRIN; TERNARY INCLUSION COMPLEX; SUSTAINED-RELEASE SYSTEM; PICK-C-DISEASE; IN-VITRO; ALPHA-CYCLODEXTRIN; PEGYLATED INSULIN; BIOCLEAVABLE POLYROTAXANES; FULMINANT-HEPATITIS; GAMMA-CYCLODEXTRINS;

D O I：

10.1248/cpb.c16-00779

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyclodextrins (CyDs) are extensively used in various fields, and especially have been widely utilized as pharmaceutical excipients and drug carriers in the pharmaceutical field. Owing to the multi -functional and biocompatible characteristics, CyDs can improve the undesirable properties of drug molecules. This review outlines the current application of CyDs in pharmaceutical formulations, focusing on their use as CyD-based drug carriers for several kinds of drugs. Additionally, CyDs have great potential as active pharmaceutical ingredients against various diseases with few side effects.

引用

页码：341 / 348

页数：8

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