Overview of Neuropeptides: Awakening the Senses?

被引:117
|
作者
Russo, Andrew F. [1 ,2 ]
机构
[1] Univ Iowa, Dept Neurol, Dept Mol Physiol & Biophys, Iowa City, IA 52242 USA
[2] Vet Affairs Med Ctr, Iowa City, IA 52246 USA
来源
HEADACHE | 2017年 / 57卷
关键词
neuropeptide; CGRP; neuromodulation; GENE-RELATED PEPTIDE; TRIGEMINOVASCULAR PATHWAY; EXOCYTOSIS; RELEASE; CGRP; MECHANISMS; NEURONS; SOMATA; NPY;
D O I
10.1111/head.13084
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Humans have a diverse collection of neuropeptides that can influence a multitude of activities. There are now over 100 known neuropeptides and probably many more yet to be identified from the over 1000 predicted peptides encoded in the genome. While diverse, peptides generally share three common characteristics: (1) post-translational processing and release from vesicles, (2) activation of cell-surface receptors over a relatively large distance, and (3) modulation of target cells that are often in the brain and periphery. Within the brain, neuropeptides can modulate the activity of co-released neurotrans mitters to either increase or decrease the strength of synaptic signaling. Within the periphery, neuropeptides can function similar to peptide hormones and modulate nearly all bodily functions. Given the clear involvement of the neuropeptide CGRP in migraine and the emerging evidence for other peptides, it seems likely that neuropeptides may help awaken the senses and contribute to the heightened sensory state of migraine.
引用
收藏
页码:37 / 46
页数:10
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