Convalescent plasma: A potential therapeutic option for COVID-19 patients

被引：4
|
作者：
Ng, Swee [1 ]
Soon, Tsuey [2 ]
Yap, Wei [2 ]
Liew, Kai [3 ]
Lim, Ya [4 ]
Ming, Long [4 ]
Tang, Yin-Quan [2 ]
Goh, Bey [1 ,5 ]
机构：
[1] Monash Univ Malaysia, Sch Pharm, Biofunct Mol Exploratory Res Grp BMEX, Bandar Sunway, Malaysia
[2] Taylors Univ, Sch Biosci, Fac Med & Hlth Sci, Subang Jaya, Selangor, Malaysia
[3] Univ Cyberjaya, Fac Pharm, Cyberjaya, Selangor, Malaysia
[4] Univ Brunei Darussalam, PAP Rashidah Saadatul Bolkiah Inst Hlth Sci, Gadong, Brunei
[5] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2020年 / 13卷 / 11期
关键词：
INFECTION; DISEASE; SPIKE;
D O I：
10.4103/1995-7645.291408
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The new coronavirus disease (COVID-19) outbreak has challenged us to take unprecedented steps to bring this pandemic under control. In view of the urgency of this situation, convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current pandemic. This is mainly due to the fact that convalescent plasma has been studied in a few case series with promising outcomes. In addition, on-going large clinical trials aimed to further evaluate the effectiveness, safety, and optimal dosage, duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising results. Therefore, this article aims to provide an overview of possible mechanisms of actions of convalescent plasma, its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.
引用
收藏
页码：477 / 486
页数：10
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