Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver

被引：0
|
作者：
Sastre, J [1 ]
Lloret, A
Borrás, C
Pereda, J
García-Sala, D
Droy-Lefaix, MT
Pallardo, FV
Viña, J
机构：
[1] Univ Valencia, Fac Med, Dept Fisiol, Valencia, Spain
[2] IPSEN, F-75016 Paris, France
来源：
CELLULAR AND MOLECULAR BIOLOGY | 2002年 / 48卷 / 06期
关键词：
oxidative stress; peroxide production; glutathione; flavonoids; membrane potential; apoptosis;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
According to the free radical theory of aging, oxygen-derived free radicals causes the age-associated impairment at the cellular and tissue levels. The mitochondrial theory of aging points to mitochondria, and specially mitochondrial DNA, as the major targets of free radical attack upon aging. Thus, oxidative damage to mtDNA accumulate with age in human and rodent tissues and also is inversely related to maximum life span of mammals. Mitochondrial deficits, such as a decrease in mitochondrial membrane potential, occur upon aging due to oxidative damage. The age-related mitochondrial oxidative stress may be prevented by late onset administration of certain antioxidants, such as Ginkgo biloba extract EGb 761. These antioxidants may also delay the physiological impairment associated with aging.
引用
收藏
页码：685 / 692
页数：8
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