Hemophagocytic syndrome as the initial manifestation of CD20(+) B-cell non-Hodgkin lymphoma with EGFR(+) lung adenocarcinoma: a case report and literature review

We report a case of CD20(+) B-cell non-Hodgkin lymphoma (NHL) with hemophagocytic syndrome (HLH) as the initial manifestation, which was found in a 51-year-old female. After being treated with R-CHOP regimen chemotherapy, the patient's HLH was controlled, but the chest computed tomography (CT) showed no significant changes in the left upper lung lesions. The patient was diagnosed with lung adenocarcinoma after a percutaneous lung biopsy and the determination of the mutation of exon 21 L858R in the epidermal growth factor receptor (EGFR) gene. The patient received R-GDP scheme chemotherapy and icotinib targeted therapy. After the treatment, her chest CT showed that the left upper lung cancer lesions were more absorbed than before.