Modified cells as potential ocular drug delivery systems

被引：1
|
作者：
Tennikova, Tatiana [1 ]
Urtti, Arto [1 ,2 ,3 ]
机构：
[1] St Petersburg State Univ, Inst Chem, St Petersburg, Russia
[2] Univ Helsinki, Fac Pharm, Helsinki, Finland
[3] Univ Eastern Finland, Sch Pharm, Kuopio, Finland
来源：
DRUG DISCOVERY TODAY | 2019年 / 24卷 / 08期
关键词：
CILIARY NEUROTROPHIC FACTOR; PIGMENT EPITHELIAL-CELLS; MESENCHYMAL STEM-CELLS; RED-BLOOD-CELLS; GENE-THERAPY; BONE-MARROW; NANOPARTICLES; MACROPHAGES; EXPRESSION; IMPLANTS;
D O I：
10.1016/j.drudis.2018.12.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Drug delivery to ocular targets is problematic, especially in retinal disease treatment. Therefore, targeted drug delivery, prolonged drug action, and minimally invasive treatments are needed. In this review, we describe cell technologies for drug delivery. These technologies are based on genetic engineering and nongenetic-based approaches for cell modification. In principle, cell technologies enable targeted delivery, long drug action, and minimally invasive administration, but they have only been sparsely studied for ocular drug delivery. Herein, these technologies are discussed in the ocular context.
引用
收藏
页码：1621 / 1626
页数：6
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