Porous and modified HA particles as potential drug delivery systems

被引：30
|
作者：
Sahiner, Nurettin [1 ,2 ]
Silan, Coskun [2 ,3 ]
Sagbas, Selin [3 ]
Ilgin, Pinar [3 ]
Butun, Sultan [3 ]
Erdugan, Huseyin [2 ,4 ]
Ayyala, Ramesh S. [5 ]
机构：
[1] Canakkale Onsekiz Mart Univ, Sch Med, Dept Chem, TR-17100 Canakkale, Turkey
[2] Canakkale Onsekiz Mart Univ, Nanosci & Technol Res & Applicat Ctr NANORAC, TR-17100 Canakkale, Turkey
[3] Canakkale Onsekiz Mart Univ, Dept Pharmacol, Sch Med, TR-17100 Canakkale, Turkey
[4] Canakkale Onsekiz Mart Univ, Dept Biol, Fac Sci & Arts, TR-17100 Canakkale, Turkey
[5] Tulane Univ, Sch Med, Dept Ophthalmol, New Orleans, LA 70112 USA
来源：
MICROPOROUS AND MESOPOROUS MATERIALS | 2012年 / 155卷
关键词：
HA microgels; HA composites; Porous HA; Modified HA particles; Drug delivery; VOCAL FOLD REGENERATION; HYALURONIC-ACID; HYDROGEL PARTICLES; SILICA PARTICLES; NETWORKS; TEOS; PH;
D O I：
10.1016/j.micromeso.2012.01.027
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Composite silica-hyaluronic acid (Si-HA) micro particles were synthesized, employing tetraethyl orthosilicate (TEOS) in the presence of linear HA and a crosslinker, divinyl sulfone (DVS) via a water-in-oil microemulsion polymerization technique. Porous HA (PHA) hydrogel particles were generated after removal of silica particles upon treatment of HA composites with hydrofluoric acid (FIF). Furthermore, HA particles were quaternized (QHA) by chemical modification using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride as a quarternization agent. The size of HA based particles were ranged between 1.26 and 2.95 mu m. The PHA particles have a surface area of 2.7 m(2)/g confirmed by the surface area measurements. Modified HA particles were used in the absorption and release studies of two model drugs in PBS, trimethoprim (TMP) and sodium diclofenac (SDF) which are acidic and basic in nature, respectively. The ability to control the size, charge and porosity of the HA particles which showed almost linear drug release profiles. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：124 / 130
页数：7
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