Integrated bacterial genomics for the discovery of novel antimicrobials

被引：11
|
作者：
Loferer, H
Jacobi, A
Posch, A
Gauss, C
Meier-Ewert, S
Seizinger, B
机构：
[1] Genome Pharmaceut Corp, D-82152 Martinsried, Germany
[2] TOPLAB, Gesell Angew Biotechnol, D-82152 Martinsried, Germany
来源：
DRUG DISCOVERY TODAY | 2000年 / 5卷 / 03期
关键词：
D O I：
10.1016/S1359-6446(99)01455-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Sequencing of bacterial genomes has been progressing with breathtaking speed. Currently, the genomes of 23 bacterial species are sequenced, with approximately 40 more sequencing projects in progress. Industrial research is now facing the challenge of translating this information efficiently into drug discovery. This review will summarize the impact of bacterial genomics, bioinformatics and second-generation genomic technologies on target identification, assay development, lead optimization and compound characterization.
引用
收藏
页码：107 / 114
页数：8
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