Advances in gene delivery through molecular design of cationic lipids

被引：250
|
作者：
Bhattacharya, Santanu [1 ,2 ]
Bajaj, Avinash [1 ]
机构：
[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India
[2] Chem Biol Unit JNCASR, Bangalore 560064, Karnataka, India
来源：
CHEMICAL COMMUNICATIONS | 2009年 / 31期
关键词：
ANGLE-NEUTRON-SCATTERING; LIPOSOME-DNA COMPLEXES; CELL-TRANSFECTION PROPERTIES; FATTY-ACID CHAINS; TRANSFER IN-VIVO; GEMINI SURFACTANTS; PLASMID DNA; VESICLE FORMATION; EFFICIENT TRANSFECTION; AGGREGATION PROPERTIES;
D O I：
10.1039/b900666b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure-activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.
引用
收藏
页码：4632 / 4656
页数：25
相关论文
共 50 条
  • [1] The design of cationic lipids for gene delivery
    Martin, B
    Sainlos, M
    Aissaoui, A
    Oudrhiri, N
    Hauchecorne, M
    Vigneron, JP
    Lehn, JM
    Lehn, P
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (03) : 375 - 394
  • [2] Cationic nucleoside lipids for gene delivery
    Chabaud, P
    Camplo, M
    Payet, D
    Serin, G
    Moreau, L
    Barthélémy, P
    Grinstaff, MW
    [J]. BIOCONJUGATE CHEMISTRY, 2006, 17 (02) : 466 - 472
  • [3] Toxicity of cationic lipids and cationic polymers in gene delivery
    Lv, Hongtao
    Zhang, Shubiao
    Wang, Bing
    Cui, Shaohui
    Yan, Jie
    [J]. JOURNAL OF CONTROLLED RELEASE, 2006, 114 (01) : 100 - 109
  • [4] Cationic lipids in gene delivery: Principles, vector design and therapeutical applications
    Ilies, MA
    Seitz, WA
    Balaban, AT
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (27) : 2441 - 2473
  • [5] Novel cationic lipids for gene delivery and gene therapy
    Byk, G
    Scherman, D
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (09) : 1125 - 1141
  • [6] Gene delivery by cationic lipids: in and out of an endosome
    Hoekstra, D.
    Rejman, J.
    Wasungu, L.
    Shi, F.
    Zuhorn, I.
    [J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2007, 35 : 68 - 71
  • [7] Cationic lipids for gene delivery in vitro and in vivo
    Rao, N. Madhusudhana
    Gopal, Vijaya
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 16 (06) : 825 - 844
  • [8] The Headgroup Evolution of Cationic Lipids for Gene Delivery
    Zhi, Defu
    Zhang, Shubiao
    Cui, Shaohui
    Zhao, Yinan
    Wang, Yinhuan
    Zhao, Defeng
    [J]. BIOCONJUGATE CHEMISTRY, 2013, 24 (04) : 487 - 519
  • [9] Rational design of cationic lipids for siRNA delivery
    Sean C Semple
    Akin Akinc
    Jianxin Chen
    Ammen P Sandhu
    Barbara L Mui
    Connie K Cho
    Dinah W Y Sah
    Derrick Stebbing
    Erin J Crosley
    Ed Yaworski
    Ismail M Hafez
    J Robert Dorkin
    June Qin
    Kieu Lam
    Kallanthottathil G Rajeev
    Kim F Wong
    Lloyd B Jeffs
    Lubomir Nechev
    Merete L Eisenhardt
    Muthusamy Jayaraman
    Mikameh Kazem
    Martin A Maier
    Masuna Srinivasulu
    Michael J Weinstein
    Qingmin Chen
    Rene Alvarez
    Scott A Barros
    Soma De
    Sandra K Klimuk
    Todd Borland
    Verbena Kosovrasti
    William L Cantley
    Ying K Tam
    Muthiah Manoharan
    Marco A Ciufolini
    Mark A Tracy
    Antonin de Fougerolles
    Ian MacLachlan
    Pieter R Cullis
    Thomas D Madden
    Michael J Hope
    [J]. Nature Biotechnology, 2010, 28 : 172 - 176
  • [10] Rational design of cationic lipids for siRNA delivery
    Semple, Sean C.
    Akinc, Akin
    Chen, Jianxin
    Sandhu, Ammen P.
    Mui, Barbara L.
    Cho, Connie K.
    Sah, Dinah W. Y.
    Stebbing, Derrick
    Crosley, Erin J.
    Yaworski, Ed
    Hafez, Ismail M.
    Dorkin, J. Robert
    Qin, June
    Lam, Kieu
    Rajeev, Kallanthottathil G.
    Wong, Kim F.
    Jeffs, Lloyd B.
    Nechev, Lubomir
    Eisenhardt, Merete L.
    Jayaraman, Muthusamy
    Kazem, Mikameh
    Maier, Martin A.
    Srinivasulu, Masuna
    Weinstein, Michael J.
    Chen, Qingmin
    Alvarez, Rene
    Barros, Scott A.
    De, Soma
    Klimuk, Sandra K.
    Borland, Todd
    Kosovrasti, Verbena
    Cantley, William L.
    Tam, Ying K.
    Manoharan, Muthiah
    Ciufolini, Marco A.
    Tracy, Mark A.
    de Fougerolles, Antonin
    MacLachlan, Ian
    Cullis, Pieter R.
    Madden, Thomas D.
    Hope, Michael J.
    [J]. NATURE BIOTECHNOLOGY, 2010, 28 (02) : 172 - U18
12345