IL-10-producing CD4+ T cells negatively regulate fucosylation of epithelial cells in the gut

被引：22

作者：

Goto, Yoshiyuki ^{[1
,3
,8
,13
]}

Lamichhane, Aayam ^{[1
,2
,3
,4
]}

Kamioka, Mariko ^{[1
,3
,4
,5
,6
]}

Sato, Shintaro ^{[1
,3
]}

Honda, Kenya ^{[3
,7
]}

Kunisawa, Jun ^{[1
,4
,8
,9
,10
,11
]}

Kiyono, Hiroshi ^{[1
,2
,3
,5
,6
,8
,12
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Mucosal Immunol, Tokyo, Japan

[2] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Chiba, Japan

[3] Japan Sci & Technol Agcy, CREST, Tokyo, Japan

[4] NIBIOHN, Lab Vaccine Mat, Osaka, Japan

[5] Univ Tokyo, Grad Sch Sci, Tokyo 113, Japan

[6] Univ Tokyo, Fac Med, Tokyo 113, Japan

[7] RIKEN Ctr Integrat Med Sci IMS, Kanagawa, Japan

[8] Univ Tokyo, Inst Med Sci, Int Res & Dev Ctr Mucosal Vaccines, Tokyo, Japan

[9] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka, Japan

[10] Osaka Univ, Grad Sch Dent, Osaka, Japan

[11] Kobe Univ, Grad Sch Med, Dept Microbiol & Infect Dis, Kobe, Hyogo 657, Japan

[12] Chiba Univ, Grad Sch Med, Dept Immunol, Chiba, Japan

[13] Chiba Univ, Div Mol Immunol, Med Mycol Res Ctr, Chiba, Japan

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

日本科学技术振兴机构;

关键词：

SECRETOR STATUS; HOST; ANTIGENS; MICE; INTERLEUKIN-10; EXPRESSION; SURFACE; LYMPHOCYTES; MICROBIOTA; RESPONSES;

D O I：

10.1038/srep15918

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4(+) T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T cells, especially those expressing alpha beta T cell receptor (TCR), CD4, and IL-10. No such effect was observed in mice lacking B cells. Adoptive transfer of alpha beta TCR+ CD4(+) T cells from normal mice, but not IL-10-deficient mice, normalized fucosylation of ECs. These findings suggest that IL-10-producing CD4(+) T cells contribute to the maintenance of the function of ECs by regulating their fucosylation.

引用

页数：11

共 50 条

[41] Cord-Blood-Derived Mesenchymal Stromal Cells Downmodulate CD4+ T-Cell Activation by Inducing IL-10-Producing Th1 Cells
Selleri, Silvia
Dieng, Mame Massar
Nicoletti, Simon
Louis, Isabelle
Beausejour, Christian
Le Deist, Francoise
Haddad, Elie
[J]. STEM CELLS AND DEVELOPMENT, 2013, 22 (07) : 1063 - 1075
[42] The Family of IL-10-Secreting CD4+ T Cells
Fujio, Keishi
Okamura, Tomohisa
Yamamoto, Kazuhiko
[J]. ADVANCES IN IMMUNOLOGY, VOL 105, 2010, 105 : 99 - 130
[43] Plasmacytoid dendritic cells regulate recall responses by rapid induction of IL-10 in CD4+ memory T cells
Kvale, E. Osthagen
Floysand, Y.
Lund-Johansen, F.
Rollag, H.
Brandtzaeg, P.
Jahnsen, F. L.
Olweus, J.
[J]. TISSUE ANTIGENS, 2006, 67 (06): : 443 - 444
[44] Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells
Bakdash, G.
Vogelpoel, L. T. C.
van Capel, T. M. M.
Kapsenberg, M. L.
de Jong, E. C.
[J]. MUCOSAL IMMUNOLOGY, 2015, 8 (02) : 265 - 278
[45] IL-27-producing CD4+ T cells regulate protective immune responses during malaria infection
Kimura, D.
Doe, H.
Miyakoda, M.
Kimura, K.
Hara, H.
Yoshida, H.
Yui, K.
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 557 - 558
[46] Preferential localization of IL-10-producing regulatory T cells to mucosal tissues
Maynard, Craig L.
Harrington, Laurie E.
Janowski, Karen M.
Weaver, Casey T.
[J]. JOURNAL OF IMMUNOLOGY, 2006, 176 : S217 - S217
[47] Identification of tonsillar CD4+CD25-LAG3+ T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue
Sumitomo, Shuji
Nakachi, Shinichiro
Okamura, Tomohisa
Tsuchida, Yumi
Kato, Rika
Shoda, Hirofumi
Furukawa, Asayo
Kitahara, Nobuo
Kondo, Kenji
Yamasoba, Tatsuya
Yamamoto, Kazuhiko
Fujio, Keishi
[J]. JOURNAL OF AUTOIMMUNITY, 2017, 76 : 75 - 84
[48] IL-10-producing T regulatory type 1 cells and oral tolerance
Battaglia, M
Gianfrani, C
Gregori, S
Roncarolo, MG
[J]. ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION, 2004, 1029 : 142 - 153
[49] Human IL-10 producing regulatory B cells control CD4+ T cell proliferation
Bouaziz, Jean-David
Calbo, Sebastien
Maho-Vaillant, Maud
Saussine, Anne
Bagot, Martine
Bensussan, Armand
Musette, Philippe
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 : S2 - S2
[50] Human IL-10 producing regulatory B cells control CD4+ T cell proliferation
Bouaziz, J. -D.
Calbo, S.
Maho-Vaillant, M.
Saussine, A.
Bagot, M.
Bensussan, A.
Musette, P.
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 (10) : 2523 - 2523

← 1 2 3 4 5 →