An efficient regioselective copper catalyzed multi-component synthesis of 1,3-disubstituted pyrazoles

被引：18

作者：

Raghunadh, Akula ^{[1
]}

Meruva, Suresh Babu ^{[1
]}

Mekala, Ramamohan ^{[1
]}

Rao, K. Raghavendra ^{[1
]}

Krishna, Thalishetti ^{[1
]}

Chary, R. Gangadhara ^{[1
]}

Rao, L. Vaikunta ^{[2
]}

Kumar, U. K. Syam ^{[3
]}

机构：

[1] Dr Reddys Labs Ltd, Custom Pharmaceut Serv, Technol Dev Ctr, Hyderabad 500049, Andhra Pradesh, India

[2] Gitam Univ, GIS, Dept Chem, Visakhapatnam, Andhra Pradesh, India

[3] Dr Reddys Labs Ltd, Integrated Prod Dev, Hyderabad 500049, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 18期

关键词：

Pyrazoles; Multicomponent reaction; Michael addition; Cu catalyst and Ullmann cross-coupling reaction; 1,3-DIPOLAR CYCLOADDITIONS; SUBSTITUTED PYRAZOLES; ARYLATION; STRAIGHTFORWARD; CYCLIZATION; CELECOXIB; ULLMANN;

D O I：

10.1016/j.tetlet.2014.03.125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of unsymmetrically substituted 1,3-pyrazole derivatives has been developed via three-component coupling reaction involving 3-(dimethylamino)-1-phenylprop-2-en-1-one, hydrazine, and aryl halides in one pot process exhibiting high regioselectivity. The pyrazole synthesis proceeds via a sequential series of reactions such as Michael addition, heterocyclization, dehydration, and Ullmann cross-coupling. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2986 / 2990

页数：5

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