Significance of Autophagy in Dengue Virus Infection: A Brief Review

被引：13

作者：

Acharya, Bishwanath ^{[1
]}

Gyeltshen, Sonam ^{[1
]}

Chaijaroenkul, Wanna ^{[1
]}

Na-Bangchang, Kesara ^{[1
,2
]}

机构：

[1] Thammasat Univ, Rangsit Ctr, Chulabhom Int Coll Med, Klongluang, Thailand

[2] Thammasat Univ, Rangsit Ctr, Ctr Excellence Pharmacol & Mol Biol Malaria & Cho, Chulabhorn Int Coll Med, 99 Moo 18 Paholyothin Rd, Klongluang, Thailand

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2019年 / 100卷 / 04期

关键词：

HEPATITIS-C VIRUS; VIRAL REPLICATION; PROTEIN; CELLS; INHIBITION; ANTIBODIES; INFLAMMATION; ACTIVATION; MECHANISMS; MACROPHAGE;

D O I：

10.4269/ajtmh.18-0761

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Dengue virus (DENV) causes asymptomatic to severe life-threatening infections and affects millions of people worldwide. Autophagy, a cellular degradative pathway, has both proviral and antiviral functions. Dengue virus triggers the autophagy pathway for the successful replication of its genome. However, the exact mechanism and the viral factors involved in activating this pathway remain unclear. This review summarizes the existing knowledge on the mechanism of autophagy induction and its significance during DENV infection.

引用

页码：783 / 790

页数：8

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