It takes a PHD to read the histone code

被引：172
|
作者：
Mellor, Jane [1 ]
机构：
[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England
来源：
CELL | 2006年 / 126卷 / 01期
关键词：
D O I：
10.1016/j.cell.2006.06.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes.
引用
收藏
页码：22 / 24
页数：3
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