Effects of Maytenus ilicifolia on reproduction and embryo-fetal development in Wistar rats

被引：4
|
作者：
Cunha-Laura, A. L. [1 ]
Auharek, S. A. [1 ]
Oliveira, R. J. [2 ]
Siqueira, J. M. [3 ]
Vieira, M. C. [4 ]
Leite, V. S. [5 ]
Portugal, L. C. [1 ]
机构：
[1] Univ Fed Mato Grosso do Sul, Ctr Ciencias Biol & Saude, Campo Grande, MS, Brazil
[2] Univ Fed Mato Grosso do Sul, Fac Med, Campo Grande, MS, Brazil
[3] Univ Fed Sao Joao Del Rei, Divinopolis, MG, Brazil
[4] Fundacao Univ Fed Grande Dourados, Fac Ciencias Agr, Dourados, MS, Brazil
[5] Univ Estadual Londrina, Ctr Ciencias Biol, Londrina, PR, Brazil
来源：
GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 02期
关键词：
Maytenus ilicifolia; Toxicology; Reproduction; Embryo-fetal development; CORPUS-LUTEUM; EXPOSURE; MART; TRITERPENES; PREGNANCY;
D O I：
10.4238/2014.May.9.16
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Maytenus ilicifolia (Celastraceae), popularly known as espinheira-santa, is a native plant from the Atlantic forest and is commonly used in popular medicine to treat inflammation and as an abortifacient. To evaluate the effects of M. ilicifolia on pregnant rats during the organogenic period (T1) or throughout the gestational period (T2), an extract obtained using an acetone-water mixture at a 70: 30 ratio was administered via gavage at a dose of 15.11 mg.kg(-1).day(-1) over 2 treatment periods (T1 and T2). No clinical signs of maternal toxicity were observed. Term fetuses did not present malformations or anomalies as the number of implantations, reabsorptions, live, and dead fetuses were similar to the control group. In conclusion, M. ilicifolia hydroacetonic extract is non-toxic to pregnant rats and appears to not interfere with the progress of embryo-fetal development.
引用
收藏
页码：3711 / 3720
页数：10
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