An efficient Darzens reaction promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)

被引：3
|
作者：
Luo, Juan [1 ]
Hu, Lanfang [1 ]
Zhang, Minghao [1 ]
Tang, Qiang [1 ]
机构：
[1] Chongqing Med Univ, Coll Pharm, Chongqing Res Ctr Pharmaceut Engn, Ctr Lab Teaching & Management, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China
来源：
TETRAHEDRON LETTERS | 2019年 / 60卷 / 30期
关键词：
DBU; Darzens reaction; alpha; beta-Epoxy ketone; alpha-Haloketone; ASYMMETRIC DARZENS; EPOXIDE; CONDENSATION; ALDEHYDES; CATALYSTS; AGENT;
D O I：
10.1016/j.tetlet.2019.06.034
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient DBU promoted Darzens reaction utilising alpha-haloketones containing an enolizable alpha'-hydrogen is reported. This method diastereoselectively afforded the corresponding alpha,beta-epoxy ketones good to excellent yields in an one-pot reaction without using any transition metals or additives. Furthermore, haloketones without an alpha'-hydrogen are also applicable in this reaction. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1949 / 1951
页数：3
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