Polymorphisms of Promoter Region of TNF-α Gene in Iranian Azeri Turkish Patients with Behcet's Disease

被引:12
|
作者
Abdolmohammadi, Reza [1 ,2 ]
Bonyadi, Mortaza [1 ,3 ]
机构
[1] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran
[2] Univ Tabriz, Dept Biol, Fac Nat Sci, Tabriz, Iran
[3] Univ Tabriz, Fac Nat Sci, Dept Mol Med Genet, Ctr Excellence Biodivers, Tabriz 51368, Iran
关键词
Behcet's Disease; Tumor Necrosis Factor-alpha; Iranian Azeri Turks; Polymorphism; ASSOCIATION; SUSCEPTIBILITY; HLA-B51;
D O I
10.3346/jkms.2017.32.1.33
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Behcet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. Alterations of the tumor necrosis factor (TNF) expression related to the polymorphic alleles of TNF gene may implicate a pathogenetic role in increased activity of this cytokine in BD. A current study aimed at investigating the possible association between BD and its clinical features in Iranian Azeri Turks with two functional TNF-alpha gene polymorphisms (at the positions of -238 and -857). A total number of 166 Iranian subjects were enrolled into two different groups; patients with BD (n = 64), and ethnically matched healthy controls (n = 101). The genotype distributions of BD patients and healthy controls were determined. The frequency of TNF-alpha -857C allele was significantly higher in Behcet's patients than that of healthy controls (P = 0.001; odds ratio [OR]= 2.616; 95% confidence interval [CI] = 1.129-6.160), whereas the frequency of TNF-alpha -238A allele was similar in both groups. The sole TNF-alpha haplotype-857C-1031C, was associated with an increase in the risk of developing BD. The TNF-alpha -857C allele was considerably associated with BD in this cohort. The findings of this study, collectively, indicate that TNF-alpha -857C-1031C haplotype located in the promoter region of the gene could exert major influence on the susceptibility to BD.
引用
收藏
页码:33 / 37
页数:5
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