Non-Canonical Roles of Dengue Virus Non-Structural Proteins

被引：23
|
作者：
Zeidler, Julianna D. [1 ]
Fernandes-Siqueira, Lorena O. [1 ]
Barbosa, Glauce M. [1 ]
Da Poian, Andrea T. [1 ]
机构：
[1] Univ Fed Rio Janeiro, Inst Bioquim Med Leopoldo Meis, Carlos Chagas Filho,373,CCS,Bl E,sala 18, BR-2194190 Rio De Janeiro, Brazil
来源：
VIRUSES-BASEL | 2017年 / 9卷 / 03期
关键词：
dengue virus; non-structural proteins; physiopathology; immunity; metabolism; FATTY-ACID SYNTHASE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; NS1; PROTEIN; ENDOTHELIAL-CELLS; INNATE IMMUNITY; ADHESION MOLECULES; VIRAL REPLICATION; GLYCOPROTEIN NS1; BINDING-PROTEIN; NS4B PROTEIN;
D O I：
10.3390/v9030042
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among members of a same family, but others being unique for each virus species. These non-canonical functions probably have evolved independently and may serve as the base to the development of specific therapies for each of those diseases. Here it is discussed what is currently known about the non-canonical roles of dengue virus (DENV) non-structural proteins (NSPs), which may account for some of the effects specifically observed in DENV infection, but not in other members of the Flaviviridae family. This review explores how DENV NSPs contributes to the physiopathology of dengue, evasion from host immunity, metabolic changes, and redistribution of cellular components during infection.
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页数：16
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