New Nitrogenous Bisabolene-Type Sesquiterpenes from a Formosan Sponge Axinyssa sp.

被引：5
|
作者：
Liu, Wangta [1 ]
Liang, Kai-Ju [2 ,3 ]
Chiang, Ching-Ying [4 ]
Lu, Mei-Chin [2 ,3 ]
Su, Jui-Hsin [2 ,3 ,5 ]
机构：
[1] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung 807, Taiwan
[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan
[3] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan
[4] Natl Kaohsiung Marine Univ, Ctr Gen Studies, Kaohsiung 811, Taiwan
[5] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2014年 / 62卷 / 04期
关键词：
sponge; Axinyssa sp; bisabolene-type; cytotoxicity; TUMOR-CELL-LINES; MARINE SPONGE; GENUS AXINYSSA; APLYSINOIDES; METABOLITES; VARIABILIS; ASSAY;
D O I：
10.1248/cpb.c13-00851
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues. Compound 1 exhibited moderate to weak cytotoxicity against Molt 4 and K562 cancer cell lines.
引用
收藏
页码：392 / 394
页数：3
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