Chemical and photo-induced nuclease activity of a novel minor groove DNA binder Cu(II) complex

被引：4

作者：

Yildiz, Ufuk ^{[1
]}

Coban, Burak ^{[1
]}

机构：

[1] Bulent Ecevit Univ, Fac Arts & Sci, Dept Chem, TR-67100 Zonguldak, Turkey

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2019年 / 84卷 / 06期

关键词：

Cu(II)-phenanthroline; chemical nuclease activity; DNA-binding affinity; minor groove binding; LIGAND COPPER(II) COMPLEXES; RUTHENIUM(II) COMPLEXES; II COMPLEXES; BINDING; ANTICANCER; CLEAVAGE; 1,10-PHENANTHROLINES; ANTIOXIDANT; INHIBITION;

D O I：

10.2298/JSC180802102Y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new type of copper(II) metal complex containing 1,10-phenanthroline (phen) and 8-(difluoromethoxy)-3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole (dtb) ligands was prepared and characterized. The ds-DNA interaction of the complex was studied by UV-Vis spectrophotometry, competitive fluorometric titration with ethidium bromide (EB) and 4',6-diamidino-2-phenylindole (DAPI), viscosity measurements and agarose gel electrophoresis. The results show that the complex can bind to ds-DNA in the minor groove by displacing DAPI molecules. DNA cleavage mechanism studies revealed that hydrogen peroxide radicals are responsible for DNA oxidative cleavage.

引用

页码：563 / 574

页数：12

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