Proteomics of Bordetella pertussis whole-cell and acellular vaccines

被引：6
|
作者：
Moeller, Jens [1 ]
Kraner, Max Edmund [2 ]
Burkovski, Andreas [1 ]
机构：
[1] Friedrich Alexander Univ Erlangen Nurnberg, Staudtstr 5, D-91058 Erlangen, Germany
[2] Friedrich Alexander Univ Erlangen Nurnberg, Lehrstuhl Biochem, Erlangen, Germany
来源：
BMC RESEARCH NOTES | 2019年 / 12卷 / 1期
关键词：
Bordetella; DTP vaccine; LC-MS; MS; Mass spectrometry; Pertussis; Vaccination; Whooping cough;
D O I：
10.1186/s13104-019-4373-2
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
ObjectivesBordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host-pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry.Data descriptionLC-MS/MS spectra were generated and analyzed using B. pertussis genome data and proteins present in whole-cell and acellular pertussis vaccines were identified. Subcellular localization of proteins and presence of signal peptides was determined bioinformatically.
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页数：3
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