A portable device for in situ deposition of bioproducts

被引：21
|
作者：
Lau, Wai K. [1 ]
Sofokleous, Panagiotis [1 ]
Day, Richard [2 ]
Stride, Eleanor [3 ]
Edirisinghe, Mohan [1 ]
机构：
[1] UCL, Dept Mech Engn, London, England
[2] UCL, Div Med, London, England
[3] Univ Oxford, Inst Biomed Engn, Dept Engn Sci, Oxford, England
来源：
BIOINSPIRED BIOMIMETIC AND NANOBIOMATERIALS | 2014年 / 3卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
bioinspired; electrohydrodynamic; electrospinning; in situ deposition; medical device; polymers; spray gun; wound dressing; DRUG-DELIVERY SYSTEMS; CONTROLLED-RELEASE; ELECTROSPUN; NANOFIBERS; MORPHOLOGY; DRESSINGS; GELATIN; FIBERS; MATRIX; MATS;
D O I：
10.1680/bbn.13.00030
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
The electrohydrodynamic (EHD) technique has traditionally been confined to the bench-top. Recently, a portable EHD device was constructed that allows the process to be applied in a much more flexible and versatile manner. In this article, the effect of electrode and collector height on the fibers generated by EHD and wound-dressing forming capabilities of the device tested on different types of simulated wound morphologies were investigated. Dressings were also fabricated on living tissue to investigate jet behavior and product morphology. The EHD device was found to be capable of controlled deposition of micrometer-sized poly(D, L-lactide-co-glycolide) acid fibers that can form an opaque, waterproof wound dressing on human skin within a few minutes with excellent adherence.
引用
收藏
页码：94 / 105
页数：12
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