Amine-Promoted One-Pot, Multicomponent Route to Spiro-Fused-Pyran Derivatives in Aqueous Media

被引：4
|
作者：
Alizadeh, Abdolali [1 ]
Rezvanian, Atieh [1 ]
Bayat, Fahimeh [1 ]
机构：
[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
来源：
HELVETICA CHIMICA ACTA | 2014年 / 97卷 / 04期
关键词：
Pyrans; spiro-fused; Ninhydrin; Malononitrile; 1,3-Diketones, cyclic; SINGLE POT;
D O I：
10.1002/hlca.201300387
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The primary amine-promoted synthesis of spiro-fused-pyran derivatives via the three-component reaction of ninhydrin, malononitrile, and cyclic 1,3-diketo compounds is described. This new methodology affords the title compounds in high yields and short time, and with easy workup without chromatographic purification steps or extraction. All structures were confirmed by IR, H-1- and C-13-NMR spectroscopy, and mass spectroscopy. A plausible mechanism for this type of reaction is proposed (Scheme 2).
引用
收藏
页码：532 / 536
页数：5
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