The local stability of a modified multi-strain SIR model for emerging viral strains

被引:56
|
作者
Fudolig, Miguel [1 ]
Howard, Reka [1 ]
机构
[1] Univ Nebraska, Dept Stat, Lincoln, NE 68588 USA
来源
PLOS ONE | 2020年 / 15卷 / 12期
关键词
PULSE VACCINATION STRATEGY; INFLUENZA EPIDEMIC; ANTIGENIC DRIFT; VIRUS; EMERGENCE; MUMPS;
D O I
10.1371/journal.pone.0243408
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the population when a preexisting strain has reached equilbrium. We assume that this newer strain does not exhibit cross-immunity with the original strain, hence those who are vaccinated and recovered from the original strain become susceptible to the newer strain. Recent events involving the COVID-19 virus shows that it is possible for a viral strain to emerge from a population at a time when the influenza virus, a well-known virus with a vaccine readily available, is active in a population. We solved for four different equilibrium points and investigated the conditions for existence and local stability. The reproduction number was also determined for the epidemiological model and found to be consistent with the local stability condition for the disease-free equilibrium.
引用
收藏
页数:27
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