Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals

被引：164
|
作者：
Jullesson, David [1 ]
David, Florian [1 ]
Pfleger, Brian [2 ]
Nielsen, Jens [1 ,3 ]
机构：
[1] Chalmers Univ Technol, Dept Biol & Biol Engn, S-41296 Gothenburg, Sweden
[2] Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA
[3] Novo Nordisk Fdn Ctr Biosustainabil, DK-2970 Horsholm, Denmark
来源：
BIOTECHNOLOGY ADVANCES | 2015年 / 33卷 / 07期
基金：
美国国家科学基金会;
关键词：
Synthetic biology; Metabolic engineering; Cell factories; Saccharomyces cerevisiae; Escherichia coli; Industrial production; RIBOSOME BINDING-SITES; YEAST; MICROORGANISMS; BIOSYNTHESIS; EXPRESSION; PRINCIPLES; MOLECULES; DESIGN; LEVEL; RNAS;
D O I：
10.1016/j.biotechadv.2015.02.011
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：1395 / 1402
页数：8
相关论文
共 50 条
  • [21] Metabolic engineering of clostridia for the production of chemicals
    Cho, Changhee
    Jang, Yu-Sin
    Moon, Hyeon Gi
    Lee, Joungmin
    Lee, Sang Yup
    [J]. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, 2015, 9 (02): : 211 - 225
  • [22] Systems metabolic engineering for the production of chemicals
    Lee, Sang Yup
    [J]. JOURNAL OF BIOTECHNOLOGY, 2008, 136 : S16 - S16
  • [23] Synthetic methylotrophy: engineering the production of biofuels and chemicals based on the biology of aerobic methanol utilization
    Whitaker, William B.
    Sandoval, Nicholas R.
    Bennett, Robert K.
    Fast, Alan G.
    Papoutsakis, Eleftherios T.
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2015, 33 : 165 - 175
  • [24] Catalysis in the industrial production of pharmaceuticals and fine chemicals
    Roessler, F
    [J]. CHIMIA, 1996, 50 (03) : 106 - 109
  • [25] SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production
    Le Feuvre, R. A.
    Carbonell, P.
    Currin, A.
    Dunstan, M.
    Fellows, D.
    Jervis, A. J.
    Rattray, N. J. W.
    Robinson, C. J.
    Swainston, N.
    Vinaixa, M.
    Williams, A.
    Yan, C.
    Barran, P.
    Breitling, R.
    Chen, G. G.
    Faulon, J. L.
    Goble, C.
    Goodacre, R.
    Kell, D. B.
    Micklefield, J.
    Scrutton, N. S.
    Shapira, P.
    Takano, E.
    Turner, N. J.
    [J]. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2016, 1 (04) : 271 - 275
  • [26] Recent developments in synthetic biology and metabolic engineering in microalgae towards biofuel production
    Jagadevan, Sheeja
    Banerjee, Avik
    Banerjee, Chiranjib
    Guria, Chandan
    Tiwari, Rameshwar
    Baweja, Mehak
    Shukla, Pratyoosh
    [J]. BIOTECHNOLOGY FOR BIOFUELS, 2018, 11
  • [27] Can synthetic biology and metabolic engineering contribute to the microbial production of lipids and oleochemicals?
    Bornscheuer, Uwe
    [J]. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2011, 113 (09) : 1075 - 1076
  • [28] Synthetic Biology and Metabolic Engineering Approaches for Improved Production and Recovery of Bacterial Polyhydroxyalkanoates
    Pillai, Aneesh Balakrishna
    Kumar, Arjun Jaya
    Kumarapillai, Harikrishnan
    [J]. ACS Symposium Series, 2019, 1329 : 181 - 207
  • [29] Metabolic engineering and synthetic biology for isoprenoid production in Escherichia coli and Saccharomyces cerevisiae
    Govinda R. Navale
    Mahesh S. Dharne
    Sandip S. Shinde
    [J]. Applied Microbiology and Biotechnology, 2021, 105 : 457 - 475
  • [30] Recent developments in synthetic biology and metabolic engineering in microalgae towards biofuel production
    Sheeja Jagadevan
    Avik Banerjee
    Chiranjib Banerjee
    Chandan Guria
    Rameshwar Tiwari
    Mehak Baweja
    Pratyoosh Shukla
    [J]. Biotechnology for Biofuels, 11
12345