Light-Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo

被引：517
|
作者：
Cheng, Xiaju [1 ]
Sun, Rui [1 ]
Yin, Ling [1 ,2 ]
Chai, Zhifang [1 ]
Shi, Haibin [1 ]
Gao, Mingyuan [1 ,3 ]
机构：
[1] Soochow Univ, Ctr Mol Imaging & Nucl Med, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med,Jiangsu Higher, Suzhou 215123, Peoples R China
[2] Jining Univ, Dept Chem & Chem Engn, Qufu 273155, Peoples R China
[3] Chinese Acad Sci, Sch Chem & Chem Engn, Univ Chinese Acad Sci, Inst Chem, Beijing 100049, Peoples R China
来源：
ADVANCED MATERIALS | 2017年 / 29卷 / 06期
基金：
中国国家自然科学基金;
关键词：
CELLULAR UPTAKE; AGGREGATION; DNA; ORGANIZATION; UV;
D O I：
10.1002/adma.201604894
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Photocross-linkable Au nanoparticles are prepared through surface decoration of photo-labile diazirine moieties. Both in vitro and in vivo studies indicate that the light-triggered cross-linking can dramatically shift the surface plasmon resonance of Au nanoparticles to near-infrared regions, which in consequence remarkably enhances their efficacy for photothermal therapy and photoacoustic imaging of tumors in vivo.
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页数：6
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