Light-Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo

被引：517

作者：

Cheng, Xiaju ^{[1
]}

Sun, Rui ^{[1
]}

Yin, Ling ^{[1
,2
]}

Chai, Zhifang ^{[1
]}

Shi, Haibin ^{[1
]}

Gao, Mingyuan ^{[1
,3
]}

机构：

[1] Soochow Univ, Ctr Mol Imaging & Nucl Med, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med,Jiangsu Higher, Suzhou 215123, Peoples R China

[2] Jining Univ, Dept Chem & Chem Engn, Qufu 273155, Peoples R China

[3] Chinese Acad Sci, Sch Chem & Chem Engn, Univ Chinese Acad Sci, Inst Chem, Beijing 100049, Peoples R China

来源：

ADVANCED MATERIALS | 2017年 / 29卷 / 06期

基金：

中国国家自然科学基金;

关键词：

CELLULAR UPTAKE; AGGREGATION; DNA; ORGANIZATION; UV;

D O I：

10.1002/adma.201604894

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Photocross-linkable Au nanoparticles are prepared through surface decoration of photo-labile diazirine moieties. Both in vitro and in vivo studies indicate that the light-triggered cross-linking can dramatically shift the surface plasmon resonance of Au nanoparticles to near-infrared regions, which in consequence remarkably enhances their efficacy for photothermal therapy and photoacoustic imaging of tumors in vivo.

引用

页数：6

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