Enantioselective Organocatalytic Conjugate Addition of Alkenes to α,β-Enones

被引：15

作者：

Cui, Lingyun ^{[1
]}

Zhang, Long ^{[1
]}

Luo, Sanzhong ^{[1
,2
]}

Cheng, Jin-Pei ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China

[2] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Organocatalysis; Conjugate addition; Enamines; Alkenes; Enantioselectivity; ALPHA; BETA-UNSATURATED CARBONYL-COMPOUNDS; CATALYZED ASYMMETRIC 1,4-ADDITION; MICHAEL ADDITION; KETONES; REAGENTS; FUNCTIONALIZATION; 1,6-ADDITION; ALKYLATION; INSERTION; OLEFINS;

D O I：

10.1002/ejoc.201402353

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the first example of the enantioselective conjugate addition of alkenes (aromatic enamines) to enones catalyzed by chiral primary amines. The reactions encompass a plethora of alpha,beta-enones including difficult alpha-substituted vinyl ketones to give vinylation adducts in high yields with good enantioselectivity. The methodology is of synthetic potential in accessing chiral functional materials.

引用

页码：3540 / 3545

页数：6

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