Quantitative trait loci affecting health traits in Swedish dairy cattle

被引:47
|
作者
Holmberg, M [1 ]
Andersson-Eklund, L [1 ]
机构
[1] Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden
关键词
quantitative trait loci; clinical mastitis; health trait; dairy cattle;
D O I
10.3168/jds.S0022-0302(04)73391-3
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The purpose of this study was to map quantitative trait loci (QTL) affecting health traits in Swedish dairy cattle. A genome scan covering 17 chromosomes was performed. Ten grandsire families were used in a granddaughter design. Nine of the families belonged to the Swedish Red and White breed, which is related to other Nordic Ayrshire breeds, and one family was of the Swedish Holstein breed. A total of 417 bulls were genotyped for 116 microsatellite markers distributed over 17 chromosomes. Daughter yield deviations for clinical mastitis, somatic cell count (SCC), and other diseases ( OD) were included in the analysis. Least squares interval mapping using putative QTL as cofactors was applied both within and across grandsire families. Significance thresholds were set by permutation tests. In the across-family analysis, we detected 8 suggestive QTL and 3QTL significant at the genome level. The QTL affecting clinical mastitis were found on 3 chromosomes ( 9, 11, and 25), 4 QTL for SCC were found ( on chromosomes 5, 9, 11, and 23), and we detected 4 QTL for OD (on chromosomes 9, 11, 15, and 25). In addition, we found several QTL that segregated within single families but where the QTL effect was not significant in the across-family analysis. In conclusion, we were able to locate QTL for all 3 analyzed traits, and overlapping QTL for several traits were observed.
引用
收藏
页码:2653 / 2659
页数:7
相关论文
共 50 条
  • [41] Detection and confirmation of quantitative trait loci affecting traits of lifetime profit index on 23 chromosomes in Canadian Holstein cattle
    Pan, Y.
    Chesnais, J. P.
    Bissonnette, N.
    Caron, N.
    Jansen, G. B.
    Plante, Y.
    Burnside, E. B.
    JOURNAL OF ANIMAL SCIENCE, 2005, 83 : 378 - 378
  • [42] Quantitative trait loci mapping of functional traits in the German Holstein cattle population
    Kühn, C
    Bennewitz, J
    Reinsch, N
    Xu, N
    Thomsen, H
    Looft, C
    Brockmann, GA
    Schwerin, M
    Weimann, C
    Hiendleder, S
    Erhardt, G
    Medjugorac, I
    Förster, M
    Brenig, B
    Reinhardt, F
    Reents, R
    Russ, I
    Averdunk, G
    Blümel, J
    Kalm, E
    JOURNAL OF DAIRY SCIENCE, 2003, 86 (01) : 360 - 368
  • [43] Whole genome scan in chickens for quantitative trait loci affecting carcass traits
    Van Kaam, JBCHM
    Groenen, MAM
    Bovenhuis, H
    Veenendaal, A
    Vereijken, ALJ
    van Arendonk, JAM
    POULTRY SCIENCE, 1999, 78 (08) : 1091 - 1099
  • [44] Analysis of quantitative trait loci affecting metabolic traits in Drosophila melanogaster.
    Montooth, KL
    Marden, JH
    Clark, AG
    AMERICAN ZOOLOGIST, 1999, 39 (05): : 60A - 60A
  • [45] Quantitative trait loci affecting eggshell traits in an F2 population
    Tuiskula-Haavisto, M.
    Honkatukia, M.
    Preisinger, R.
    Schmutz, M.
    de Koning, D. J.
    Wei, W. H.
    Vilkki, J.
    ANIMAL GENETICS, 2011, 42 (03) : 293 - 299
  • [46] Differentiation of allelic frequencies at quantitative trait loci affecting locally adaptive traits
    Latta, RG
    AMERICAN NATURALIST, 1998, 151 (03): : 283 - 292
  • [47] Mapping of quantitative trait loci affecting quality and production traits in egg layers
    Tuiskula-Haavisto, M
    Honkatukia, M
    Vilkki, J
    de Koning, DJ
    Schulman, NF
    Mäki-Tanila, A
    POULTRY SCIENCE, 2002, 81 (07) : 919 - 927
  • [48] MAPPING QUANTITATIVE TRAIT LOCI WITH DNA MICROSATELLITES IN A COMMERCIAL DAIRY-CATTLE POPULATION
    RON, M
    BAND, M
    YANAI, A
    WELLER, JI
    ANIMAL GENETICS, 1994, 25 (04) : 259 - 264
  • [49] Estimation of genetic parameters for quantitative trait loci for dairy traits in the French Holstein population
    Druet, T.
    Fritz, S.
    Boichard, D.
    Colleau, J. J.
    JOURNAL OF DAIRY SCIENCE, 2006, 89 (10) : 4070 - 4076
  • [50] Quantitative Trait Loci and Candidate Genes Affecting Fatty Acid Composition in Cattle and Pig
    Maharani, Dyah
    Jo, Cheorun
    Jeon, Jin-Tae
    Lee, Jun Heon
    KOREAN JOURNAL FOR FOOD SCIENCE OF ANIMAL RESOURCES, 2011, 31 (03) : 325 - 338