Exposure to Mouse Allergen in US Homes Associated with Asthma Symptoms

被引:32
|
作者
Salo, Paeivi W. [1 ]
Jaramillo, Renee [2 ]
Cohn, Richard D. [2 ]
London, Stephanie J. [1 ]
Zeldin, Darryl C. [1 ]
机构
[1] NIEHS, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA
[2] Constella Grp LLC, Durham, NC USA
基金
美国国家卫生研究院;
关键词
allergy; asthma; exposure; indoor; mouse allergen; INNER-CITY CHILDREN; NUTRITION EXAMINATION SURVEY; SKIN-TEST SENSITIVITY; 3RD NATIONAL-HEALTH; ENVIRONMENTAL INTERVENTION; SUBURBAN HOMES; PREVALENCE; SENSITIZATION; POPULATION; MORBIDITY;
D O I
10.1289/ehp.11847
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
BACKGROUND: Most studies investigating the role of residential mouse allergen exposures in asthma have focused on inner-city populations. OBJECTIVE: We examined whether elevated mouse allergen levels were associated with occupants' asthma status in a nationally representative sample of U.S. households. METHODS: Data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed 831 housing units inhabited by 2,456 individuals in 75 different locations throughout the United States. The survey obtained information on demographics, household characteristics, and occupants' health status by questionnaire and environmental observations. We used a polyclonall immunoassay to assess concentrations of mouse urinary protein (M UP) in vacuumed dust collected from various indoor sites. RESULTS: Of the surveyed homes, 82% had detectable levels of MUP, and in 35% of the homes, MUP concentrations exceeded 1.6 mu g/g, a level that has been associated with increased mouse allergen sensitization rates. Current asthma, defined as having doctor-diagnosed asthma and asthma symptoms in the preceding 12 months, was positively associated with increased MUP levels. The observed association was modified by atopic status; in allergic individuals, elevated MUP levels (> 1.6 mu g/g) increased the odds of having asthma symptoms [adjusted OR = 1.93; 95% confidence interval (CI), 1.14-3.27], but we found no association in those who did not report allergies (adjusted OR = 0.69; 95% CI, 0.33-1.44). CONCLUSIONS: In allergic asthma, residential mouse allergen exposure is an important risk factor for asthma morbidity.
引用
收藏
页码:387 / 391
页数:5
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