Inhibitory effects of Shouseiryu-to on two-stage carcinogenesis .2. Anti-tumor-promoting activities of lignans from Asiasarum heterotropoides var. mandshuricum

被引：0
|
作者：
Takasaki, M
Konoshima, T
Yasuda, I
Hamano, T
Tokuda, H
机构：
[1] KYOTO PHARMACEUT UNIV, YAMASHIMA KU, KYOTO 607, JAPAN
[2] TOKYO METROPOLITAN RES LAB PUBL HLTH, SHINJUKU KU, TOKYO 169, JAPAN
[3] KYOTO PREFECTURAL UNIV MED, KAMIGYO KU, KYOTO 602, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1997年 / 20卷 / 07期
关键词：
anti-tumor-promoter; lignan; asarinin; xanthoxylol; Asiasarum heterotropoides var. mandshuricum; Shouseiryu-to;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Two lignans, asarinin (6) and xanthoxylol (7), were isolated from the radix of Asiasarum heterotropoides var. mandshuricum, which consist of a kampo prescription, Shouseiryu-to, as inhibitors of Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). These lignans also exhibited remarkable inhibitory effects on a two-stage carcinogenesis test of mouse skin and pulmonary tumors, Furthermore, it was confirmed that these hydrophobic lignans dissolved in the water decoction of Shouseiryu-to, and these lignans might be among the active consituents of this kampo prescription in terms of its anti-tumor-promoting activity.
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收藏
页码：776 / 780
页数：5
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