STUDIES ON INHIBITORS OF SKIN TUMOR PROMOTION .11. INHIBITORY EFFECTS OF FLAVONOIDS FROM SCUTELLARIA-BAICALENSIS ON EPSTEIN-BARR-VIRUS ACTIVATION AND THEIR ANTI-TUMOR-PROMOTING ACTIVITIES

被引：60
|
作者：
KONOSHIMA, T
KOKUMAI, M
KOZUKA, M
IINUMA, M
MIZUNO, M
TANAKA, T
TOKUDA, H
NISHINO, H
IWASHIMA, A
机构：
[1] GIFU PHARMACEUT UNIV, GIFU 502, JAPAN
[2] KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIKYO KU, KYOTO 602, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 02期
关键词：
SCUTELLARIA-BAICALENSIS; LABIATAE; FLAVONE; EPSTEIN-BARR VIRUS; RAJI CELL; FLOW CYTOMETRY; CELL CYCLE; 2 STAGE CARCINOGENESIS; ANTI-TUMOR-PROMOTER;
D O I：
10.1248/cpb.40.531
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To search for possible anti-tumor-promoters, fourteen flavones obtained from the root of Scutellaria baicalensis were examined for their inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Among these flavones, 5,7,2'-trihydroxy- and 5,7,2',3'-tetrahydroxyflavone showed remarkable inhibitory effects on the EBV-EA activation, and the effect of the latter on Raji cell cycle was also examined by flow cytometer. These two flavones exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
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收藏
页码：531 / 533
页数：3
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