Nutrient sensing and TOR signaling in yeast and mammals

被引：497
|
作者：
Gonzalez, Asier [1 ]
Hall, Michael N. [1 ]
机构：
[1] Univ Basel, Biozentrum, Basel, Switzerland
来源：
EMBO JOURNAL | 2017年 / 36卷 / 04期
基金：
欧洲研究理事会;
关键词：
amino acids; glucose; mammals; nutrients; RAG; TORC1; yeast; TRANSFER-RNA SYNTHETASE; AMINO-ACID CONTROL; RECEPTOR-ACTIVATED PROTEOLYSIS; DEPENDENT MTORC1 ACTIVATION; TRANSCRIPTION FACTOR STP1; EIF2-ALPHA KINASE GCN2; GTP-BINDING PROTEINS; SACCHAROMYCES-CEREVISIAE; RAG GTPASES; TUMOR-SUPPRESSOR;
D O I：
10.15252/embj.201696010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR-related diseases.
引用
收藏
页码：397 / 408
页数：12
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