Flexible, palladium-catalyzed indole and azaindole synthesis by direct annulation of chloroanilines and chloroaminopyridines with ketones

被引：123
|
作者：
Nazaré, M [1 ]
Schneider, C [1 ]
Lindenschmidt, A [1 ]
Will, DW [1 ]
机构：
[1] Aventis Pharma Deutschland GmbH, DI&A Chem, D-65926 Frankfurt, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 34期
关键词：
annulation; cyclization; indoles; nitrogen heterocycles; palladium;
D O I：
10.1002/anie.200460122
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The "ringmaster" [Pd(tBu3P)2] serves as the catalyst in the direct synthesis of indoles by annulation of ortho-chloroanilines with ketones (see picture). This versatile method can be used to synthesize a variety of functionalized indoles and azaindoles. DMA = dimethylacetarnide.
引用
收藏
页码：4526 / 4528
页数：3
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