Neuronal control of peripheral insulin sensitivity and glucose metabolism

被引：143

作者：

Ruud, Johan ^{[1
,2
,3
,4
]}

Steculorum, Sophie M. ^{[1
,2
,3
,4
]}

Bruening, Jens C. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Max Planck Inst Metab Res, Dept Neuronal Control Metab, Gleueler Str 50, D-50931 Cologne, Germany

[2] Univ Hosp Cologne, Policlin Endocrinol Diabet & Prevent Med PEDP, Kerpener Str 26, D-50924 Cologne, Germany

[3] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Joseph Stelzmann Str 26, D-50931 Cologne, Germany

[4] Univ Cologne, CMMC, Joseph Stelzmann Str 26, D-50931 Cologne, Germany

[5] Natl Ctr Diabet Res DZD, Ingolstadter Land Str 1, D-85764 Neuherberg, Germany

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

基金：

瑞典研究理事会;

关键词：

BROWN ADIPOSE-TISSUE; K-ATP CHANNELS; BODY-MASS INDEX; AGRP-NEURONS; POMC NEURONS; LEPTIN RESISTANCE; PROOPIOMELANOCORTIN NEURONS; HYPOTHALAMIC INFLAMMATION; EXPRESSING NEURONS; FEEDING-BEHAVIOR;

D O I：

10.1038/ncomms15259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The central nervous system (CNS) has an important role in the regulation of peripheral insulin sensitivity and glucose homeostasis. Research in this dynamically developing field has progressed rapidly due to techniques allowing targeted transgenesis and neurocircuitry mapping, which have defined the primary responsive neurons, associated molecular mechanisms and downstream neurocircuitries and processes involved. Here we review the brain regions, neurons and molecular mechanisms by which the CNS controls peripheral glucose metabolism, particularly via regulation of liver, brown adipose tissue and pancreatic function, and highlight the potential implications of these regulatory pathways in type 2 diabetes and obesity.

引用

页数：12

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