In vivo techniques for assessment of insulin sensitivity and glucose metabolism

被引：3

作者：

Hahn, Margaret K. ^{[1
,2
,3
,4
,5
]}

Giacca, Adria ^{[2
,5
,6
]}

Pereira, Sandra ^{[1
,6
]}

机构：

[1] Ctr Addict & Mental Hlth, Toronto, ON, Canada

[2] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[3] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Banting & Best Diabet Ctr, Toronto, ON, Canada

[6] Univ Toronto, Dept Physiol, Toronto, ON, Canada

来源：

JOURNAL OF ENDOCRINOLOGY | 2024年 / 260卷 / 03期

基金：

加拿大健康研究院;

关键词：

whole animal physiology; glucose metabolism; insulin sensitivity; glucose tolerance; TOLERANCE TEST; BLOOD-GLUCOSE; CLAMP TECHNIQUE; SEX-DIFFERENCES; MALE-MICE; HOMEOSTASIS; RESISTANCE; PYRUVATE; GLUCONEOGENESIS; SECRETION;

D O I：

10.1530/JOE-23-0308

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Metabolic tests are vital to determine in vivo insulin sensitivity and glucose metabolism in preclinical models, usually rodents. Such tests include glucose tolerance tests, insulin tolerance tests, and glucose clamps. Although these tests are not standardized, there are general guidelines for their completion and analysis that are constantly being refined. In this review, we describe metabolic tests in rodents as well as factors to consider when designing and performing these tests.

引用

页数：12

共 50 条

[1] Calcium signalling pathways modulate hepatic glucose metabolism and insulin sensitivity in vivo
Rao, RH
[J]. JOURNAL OF HYPERTENSION, 1998, 16 : S31 - S31
[2] PPARδ regulates glucose metabolism and insulin sensitivity
Lee, CH
Olson, P
Hevener, A
Mehl, I
Chong, LW
Olefsky, JM
Gonzalez, FJ
Ham, J
Kang, H
Peters, JM
Evans, RM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) : 3444 - 3449
[3] Assessment of disturbed glucose metabolism and surrogate measures of insulin sensitivity in obese children and adolescents
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[J]. NUTRITION & DIABETES, 2017, 7
[4] Assessment of disturbed glucose metabolism and surrogate measures of insulin sensitivity in obese children and adolescents
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[5] Mito-Mendelian interactions alter in vivo glucose metabolism and insulin sensitivity in healthy mice
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Connelly, Ashley W.
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Holleman, Cassie
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[6] Assessment of hepatic insulin sensitivity and glucose effectiveness
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Basu, R
Toffolo, G
Rizza, RA
Cobelli, C
[J]. DIABETES, 2004, 53 : A321 - A321
[7] Neuronal control of peripheral insulin sensitivity and glucose metabolism
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[9] GLUCOSE-METABOLISM AND INSULIN SENSITIVITY IN OBESE CHILDREN
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[10] The effects of the Mediterranean diet on glucose metabolism and insulin sensitivity
Mancini, M
[J]. ATHEROSCLEROSIS, 1997, 134 (1-2) : 14 - 14

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