In vitro leishmanicidal activity of a monoclonal antibody mimicking a yeast killer toxin

被引：27
|
作者：
Savoia, D
Avanzini, C
Conti, S
Magliani, V
Frazzi, R
Polonelli, L [1 ]
机构：
[1] Univ Turin, Dept Clin & Biol Sci, S Luigi Hosp, I-10043 Turin, Italy
[2] Univ Parma, Dept Pathol & Lab Med, Microbiol Sect, I-43100 Parma, Italy
来源：
JOURNAL OF EUKARYOTIC MICROBIOLOGY | 2002年 / 49卷 / 04期
关键词：
antibiotic activity; killer antibodies; Leishmania major; Leishmania infantum;
D O I：
10.1111/j.1550-7408.2002.tb00377.x
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose-dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype-matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa.
引用
收藏
页码：319 / 323
页数：5
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