Environmental mechanisms of orofacial clefts

被引：26

作者：

Garland, Michael A. ^{[1
,2
]}

Reynolds, Kurt ^{[1
,2
,3
]}

Zhou, Chengji J. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Davis, Dept Biochem & Mol Med, Sacramento, CA 95817 USA

[2] Univ Calif Davis, Inst Pediat Regenerat Med, Shriners Hosp Children, Sch Med, Sacramento, CA 95817 USA

[3] Univ Calif Davis, Biochem Mol Cellular & Dev Biol BMCDB Grad Grp, Davis, CA 95616 USA

来源：

BIRTH DEFECTS RESEARCH | 2020年 / 112卷 / 19期

关键词：

behavioral exposure; drinking alcohol; environmental signaling pathways; folate; occupational exposure; orofacial clefts; pathogenic factors; retinoid acid; smoking tobacco; GROWTH-FACTOR-ALPHA; ARYL-HYDROCARBON RECEPTOR; NEURAL-TUBE DEFECTS; INDUCED BIRTH-DEFECTS; MATERNAL OCCUPATIONAL-EXPOSURE; PARENTAL CIGARETTE-SMOKING; NONSYNDROMIC ORAL CLEFTS; GENOME-WIDE ASSOCIATION; RETINOIC ACID; RISK-FACTORS;

D O I：

10.1002/bdr2.1830

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Orofacial clefts (OFCs) are among the most common birth defects and impart a significant burden on afflicted individuals and their families. It is increasingly understood that many nonsyndromic OFCs are a consequence of extrinsic factors, genetic susceptibilities, and interactions of the two. Therefore, understanding the environmental mechanisms of OFCs is important in the prevention of future cases. This review examines the molecular mechanisms associated with environmental factors that either protect against or increase the risk of OFCs. We focus on essential metabolic pathways, environmental signaling mechanisms, detoxification pathways, behavioral risk factors, and biological hazards that may disrupt orofacial development.

引用

页码：1660 / 1698

页数：39

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