Self-Assembly and Evolution of Homomeric Protein Complexes

被引：62

作者：

Villar, Gabriel ^{[1
]}

Wilber, Alex W. ^{[1
]}

Williamson, Alex J. ^{[1
]}

Thiara, Parvinder ^{[1
]}

Doye, Jonathan P. K. ^{[1
]}

Louis, Ard A. ^{[2
]}

Jochum, Mara N. ^{[1
]}

Lewis, Anna C. F. ^{[1
]}

Levy, Emmanuel D. ^{[3
]}

机构：

[1] Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England

[2] Univ Oxford, Rudolf Peierls Ctr Theoret Phys, Oxford OX1 3QP, England

[3] MRC Lab Mol Biol, Cambridge CB2 0QH, England

来源：

PHYSICAL REVIEW LETTERS | 2009年 / 102卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

RECONSTITUTION; INTERFACES; SYMMETRY;

D O I：

10.1103/PhysRevLett.102.118106

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions, and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates.

引用

页数：4

共 50 条

[41] Cooperative self-assembly of discrete metal complexes
Herkert, Lorena
Sampedro, Angel
Fernandez, Gustavo
CRYSTENGCOMM, 2016, 18 (46): : 8813 - 8822
[42] THE SELF-ASSEMBLY OF COMPLEXES WITH [2]PSEUDOROTAXANE SUPERSTRUCTURES
ASHTON, PR
PHILP, D
REDDINGTON, MV
SLAWIN, AMZ
SPENCER, N
STODDART, JF
WILLIAMS, DJ
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (23) : 1680 - 1683
[43] Lattice self-assembly of cyclodextrin complexes and beyond
Wu, Chunxian
Xie, Qingqiao
Xu, Weiwei
Tu, Mei
Jiang, Lingxiang
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2019, 39 : 76 - 85
[44] Self-Assembly of Cyclodextrins and Their Complexes in Aqueous Solutions
Ryzhakov, Alexey
Thao Do Thi
Stappaerts, Jef
Bertoletti, Laura
Kimpe, Kristof
Couto, Andre Rodrigues Sa
Saokham, Phennapha
Van den Mooter, Guy
Augustijns, Patrick
Somsen, Govert W.
Kurkov, Sergey
Inghelbrecht, Sabine
Arien, Albertina
Jimidar, M. Ilias
Schrijnemakers, Koen
Loftsson, Thorsteinn
JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 105 (09) : 2556 - 2569
[45] SELF-ASSEMBLY OF THE ELECTROACTIVE COMPLEXES OF POLYANILINE AND SURFACTANT
ZHENG, WY
WANG, RH
LEVON, K
RONG, ZY
TAKA, T
PAN, W
MACROMOLECULAR CHEMISTRY AND PHYSICS, 1995, 196 (08) : 2443 - 2462
[46] Polymer clay self-assembly complexes on paper
Ou, Runqing
Zhang, Jianguo
Deng, Yulin
Ragauskas, Arthur J.
JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 105 (04) : 1987 - 1992
[47] Self-assembly of ion-pair complexes
Leong, Wei Lee
Vittal, Jagadese J.
CRYSTAL GROWTH & DESIGN, 2007, 7 (10) : 2112 - 2116
[48] Self-assembly of the complexes of bipodal thiophosphorylated thioureas
Zabirov, NG
Brusko, VV
Verat, AY
Krivolapov, DB
Litvinov, IA
Cherkasov, RA
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2002, 177 (6-7) : 1869 - 1872
[49] Self-assembly of cyclodextrin complexes: Aggregation of hydrocortisone/cyclodextrin complexes
Messner, Martin
Kurkov, Sergey V.
Brewster, Marcus E.
Jansook, Phatsawee
Loftsson, Thorsteinn
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 407 (1-2) : 174 - 183
[50] DNA Self-Assembly: From Chirality to Evolution
Timsit, Youri
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (04) : 8252 - 8270

← 1 2 3 4 5 →