Self-Assembly and Evolution of Homomeric Protein Complexes

被引：62

作者：

Villar, Gabriel ^{[1
]}

Wilber, Alex W. ^{[1
]}

Williamson, Alex J. ^{[1
]}

Thiara, Parvinder ^{[1
]}

Doye, Jonathan P. K. ^{[1
]}

Louis, Ard A. ^{[2
]}

Jochum, Mara N. ^{[1
]}

Lewis, Anna C. F. ^{[1
]}

Levy, Emmanuel D. ^{[3
]}

机构：

[1] Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England

[2] Univ Oxford, Rudolf Peierls Ctr Theoret Phys, Oxford OX1 3QP, England

[3] MRC Lab Mol Biol, Cambridge CB2 0QH, England

来源：

PHYSICAL REVIEW LETTERS | 2009年 / 102卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

RECONSTITUTION; INTERFACES; SYMMETRY;

D O I：

10.1103/PhysRevLett.102.118106

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions, and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates.

引用

页数：4

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