Immunotherapy of Acute Myeloid Leukemia: Current Approaches

被引：45
|
作者：
Smits, Evelien L. J. M. [1 ]
Berneman, Zwi N. [1 ,2 ]
Van Tendeloo, Viggo F. I. [1 ,2 ]
机构：
[1] Univ Antwerp, Fac Med, VIDI, Lab Expt Hematol, B-2650 Antwerp, Belgium
[2] Univ Antwerp Hosp, Ctr Cellular Therapy & Regenerat Med, Antwerp, Belgium
来源：
ONCOLOGIST | 2009年 / 14卷 / 03期
关键词：
Myeloid leukemia; Active immunotherapy; Passive immunotherapy; CYTOTOXIC T-LYMPHOCYTES; ACUTE MYELOGENOUS LEUKEMIA; STEM-CELL TRANSPLANTATION; COLONY-STIMULATING FACTOR; ADVANCED MYELODYSPLASTIC SYNDROME; AUTOLOGOUS DENDRITIC CELLS; MEDIATED GENE-TRANSFER; SHORT-TERM CULTURE; IN-VITRO; WT1; PEPTIDE;
D O I：
10.1634/theoncologist.2008-0165
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Following standard therapy that consists of chemotherapy with or without stem cell transplantation, both relapsed and refractory disease shorten the survival of acute myeloid leukemia (AML) patients. Therefore, additional treatment options are urgently needed, especially to fight residual AML cells. The identification of leukemia-associated antigens and the observation that administration of allogeneic T cells can mediate a graft-versus-leukemia effect paved the way to the development of active and passive immunotherapy strategies, respectively. The aim of these strategies is the eradication of AML cells by the immune system. In this review, an overview is provided of both active and passive immunotherapy strategies that are under investigation or in use for the treatment of AML. For each strategy, a critical view on the state of the art is given and future perspectives are discussed. The Oncologist 2009; 14: 240-252
引用
收藏
页码：240 / 252
页数：13
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