Comparison of epidemiology and clinical characteristics of infections by human parechovirus vs. those by enterovirus during the first month of life

被引:46
|
作者
Cabrerizo, Maria [1 ]
Trallero, Gloria [1 ]
Pena, Maria Jose [2 ]
Cilla, Amaia [4 ]
Megias, Gregoria [4 ]
Munoz-Almagro, Carmen [5 ]
Del Amo, Eva [5 ]
Roda, Diana [5 ]
Mensalvas, Ana Isabel [6 ]
Moreno-Docon, Antonio [6 ]
Garcia-Costa, Juan [7 ]
Rabella, Nuria [8 ]
Omenaca, Manuel [9 ]
Romero, Maria Pilar [10 ]
Sanbonmatsu-Gamez, Sara [11 ]
Perez-Ruiz, Mercedes [11 ]
Santos-Munoz, Maria Jose [3 ]
Calvo, Cristina [3 ]
机构
[1] Hlth Inst Carlos III, Natl Ctr Microbiol, Enterovirus Unit, Madrid, Spain
[2] Hosp Negrin de Gran Canaria, Las Palmas Gran Canaria, Spain
[3] Hosp Severo Ochoa, Dept Pediat, Madrid 28911, Spain
[4] Hosp Burgos, Burgos, Spain
[5] Hosp San Joan de Deu, Barcelona, Spain
[6] Hosp Virgen Arrixaca, Murcia, Spain
[7] Hosp Ourense, Orense, Spain
[8] Hosp Santa Creu & Sant Pau, Barcelona, Spain
[9] Hosp Miguel Servet, Zaragoza, Spain
[10] Hosp La Paz, Madrid, Spain
[11] Hosp Virgen de las Nieves, Granada, Spain
关键词
Enterovirus; Human parechovirus; Sepsis; Fever; Neonate; SEPSIS-LIKE ILLNESS; TIME RT-PCR; SAMPLES; SYSTEM; CHILDREN; INFANTS; RNA;
D O I
10.1007/s00431-015-2566-9
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence in infants < 1 month in Spain and, secondly, to analyse the clinical and epidemiological characteristics of the infected patients compared with those infected by enterovirus (EV). Infants < 1 month with neurological or systemic symptoms were included in a multicentre prospective study. EV and HPeV detection by RT-PCR and genotyping were performed in cerebrospinal fluids (CSF), sera or throat swabs. Out of the total of 84 infants studied during 2013, 32 were EV positive (38 %) and 9 HPeV positive (11 %). HPeV-3 was identified in eight cases and HPeV-5 in one. Mean age of HPeV-positive patients was 18 days. Diagnoses were fever without source (FWS) (67 %), clinical sepsis (22 %) and encephalitis (11 %). Leukocytes in blood and CSF were normal. Pleocytosis (p = 0.03) and meningitis (p = 0.001) were significantly more frequent in patients with EV infections than with HPeV. Conclusions: Although HPeV-3 infections were detected less frequently than EV, they still account for approximately 10 % of the cases analysed in infants younger than 1 month. HPeV-3 was mainly associated with FWS and without leukocytosis and pleocytosis in CSF. In these cases, HPeV screening is desirable to identify the aetiologic agent and prevent unnecessary treatment and prolonged hospitalization.
引用
收藏
页码:1511 / 1516
页数:6
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