Sodium Nitrite Inhibits Killing of Pseudomonas aeruginosa Biofilms by Ciprofloxacin

被引:1
|
作者
Zemke, Anna C. [1 ]
Kocak, Brian R. [2 ]
Bomberger, Jennifer M. [2 ]
机构
[1] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA
[2] Univ Pittsburgh, Dept Microbiol & Mol Genet, Pittsburgh, PA 15260 USA
关键词
Pseudomonas aeruginosa; biofilm; ciprofloxacin; fluoroquinolone; nitrite; nitrosative stress;
D O I
10.1128/AAC.00448-16
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.
引用
收藏
页数:4
相关论文
共 50 条
  • [21] Role of Viscoelasticity in Bacterial Killing by Antimicrobials in Differently Grown Pseudomonas aeruginosa Biofilms
    Rozenbaum, Rene T.
    van der Mei, Henny C.
    Woudstra, Willem
    de Jong, Ed D.
    Busscher, Henk J.
    Sharma, Prashant K.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (04)
  • [22] Antimicrobial activity and effectiveness of a combination of sodium hypochlorite and hydrogen peroxide in killing and removing Pseudomonas aeruginosa biofilms from surfaces
    DeQueiroz, G. A.
    Day, D. F.
    [J]. JOURNAL OF APPLIED MICROBIOLOGY, 2007, 103 (04) : 794 - 802
  • [23] Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms
    Wang, Lei
    Di Luca, Mariagrazia
    Tkhilaishvili, Tamta
    Trampuz, Andrei
    Moreno, Mercedes Gonzalez
    [J]. FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [24] Formation of hydroxyl radicals contributes to the bactericidal activity of ciprofloxacin against Pseudomonas aeruginosa biofilms
    Jensen, Peter O.
    Briales, Alejandra
    Brochmann, Rikke P.
    Wang, Hengzhuang
    Kragh, Kasper N.
    Kolpen, Mette
    Hempel, Casper
    Bjarnsholt, Thomas
    Hoiby, Niels
    Ciofu, Oana
    [J]. PATHOGENS AND DISEASE, 2014, 70 (03): : 440 - 443
  • [25] Efficacy of Phage and Ciprofloxacin Co-therapy on the Formation and Eradication of Pseudomonas aeruginosa Biofilms
    Sadhana Singh Sagar
    Rajesh Kumar
    Shilpa Deshpande Kaistha
    [J]. Arabian Journal for Science and Engineering, 2017, 42 : 95 - 103
  • [26] Efficacy of Phage and Ciprofloxacin Co-therapy on the Formation and Eradication of Pseudomonas aeruginosa Biofilms
    Sagar, Sadhana Singh
    Kumar, Rajesh
    Kaistha, Shilpa Deshpande
    [J]. ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING, 2017, 42 (01) : 95 - 103
  • [27] Pseudomonas aeruginosa Biofilms in Disease
    Lawrence R. Mulcahy
    Vincent M. Isabella
    Kim Lewis
    [J]. Microbial Ecology, 2014, 68 : 1 - 12
  • [28] Pseudomonas aeruginosa Biofilms in Disease
    Mulcahy, Lawrence R.
    Isabella, Vincent M.
    Lewis, Kim
    [J]. MICROBIAL ECOLOGY, 2014, 68 (01) : 1 - 12
  • [29] Insight to Pseudomonas aeruginosa biofilms
    Rohit, Ruhal
    Rashmi, Kataria
    [J]. RESEARCH JOURNAL OF BIOTECHNOLOGY, 2022, 17 (08): : 108 - 115
  • [30] Organoselenium Coating on Cellulose Inhibits the Formation of Biofilms by Pseudomonas aeruginosa and Staphylococcus aureus
    Tran, Phat L.
    Hammond, Adrienne A.
    Mosley, Thomas
    Cortez, Janette
    Gray, Tracy
    Colmer-Hamood, Jane A.
    Shashtri, Mayank
    Spallholz, Julian E.
    Hamood, Abdul N.
    Reid, Ted W.
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2009, 75 (11) : 3586 - 3592