Sodium Nitrite Inhibits Killing of Pseudomonas aeruginosa Biofilms by Ciprofloxacin

被引：1
|
作者：
Zemke, Anna C. [1 ]
Kocak, Brian R. [2 ]
Bomberger, Jennifer M. [2 ]
机构：
[1] Univ Pittsburgh, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA
[2] Univ Pittsburgh, Dept Microbiol & Mol Genet, Pittsburgh, PA 15260 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 01期
关键词：
Pseudomonas aeruginosa; biofilm; ciprofloxacin; fluoroquinolone; nitrite; nitrosative stress;
D O I：
10.1128/AAC.00448-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.
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页数：4
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