A drop of enantioselectivity in the Pseudomonas cepacia lipase-catalyzed ester hydrolysis is influenced by the chain length of the fatty acid

被引：7
|
作者：
Tafi, A
Manetti, F
Botta, M
Casati, S
Santaniello, E
机构：
[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy
[2] Univ Milan, Dipartimento Sci Preclin LITA Vialba, I-20157 Milan, Italy
来源：
TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 15期
关键词：
D O I：
10.1016/j.tetasy.2004.06.010
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A two-step molecular mechanics based computational procedure has been applied to explain the enantioselectivity observed in the hydrolysis of esters of primary alcohols, carried out in the presence of a lipase from Pseudomonas cepacia. This approach proved to be very effective in explaining an unpredictable drop in enantioselectivity, experimentally observed when the chain of the fatty acid was lengthened and to predict the chain length in correspondence of which the effect should have revealed itself. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2345 / 2350
页数：6
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