Cyclic guanosine 3',5'-monophosphate-mediated neuroprotection by nitric oxide in dissociated cultures of rat dorsal root ganglion neurones

被引：64
|
作者：
Thippeswamy, T [1 ]
Morris, R [1 ]
机构：
[1] UNIV LIVERPOOL, DEPT PRECLIN VET SCI, LIVERPOOL L69 3BX, MERSEYSIDE, ENGLAND
来源：
BRAIN RESEARCH | 1997年 / 774卷 / 1-2期
基金：
英国惠康基金;
关键词：
neuroprotection; nitric oxide synthase; nitric oxide; cyclic guanosine 3'; 5'-monophosphate; dorsal root ganglia; dissociated cell culture;
D O I：
10.1016/S0006-8993(97)81694-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In dissociated cultures of dorsal root ganglia (DRG) derived from 15-day-old rats, many neurones expressed nitric oxide synthase (NOS) and this expression was found to be reduced by nerve growth factor. The application of blockers of NOS caused selective death of those neurones expressing NOS, The soluble guanylate cyclase (sGC) blocker ODQ also caused neuronal death. The appearance of the neurones undergoing cell death was typical of apoptosis. This suggests that NO has a neuroprotective action in DRG neurones which is probably mediated by its activation of cyclic guanosine 3',5'-monophosphate. These observations are discussed in relation to the developmental and neuropathic changes in NOS expression by DRG neurones. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：116 / 122
页数：7
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