In vitro cell tests of pancreatic malignant tumor cells by photothermotherapy based on DMSO porous silicon colloids

被引：4
|
作者：
Hong, Chanseok [1 ]
Lee, Chongmu [1 ]
机构：
[1] Inha Univ, Dept Mat Sci & Engn, Inchon 402751, South Korea
来源：
LASERS IN MEDICAL SCIENCE | 2014年 / 29卷 / 01期
关键词：
Porous silicon nanoparticles; Photothermotherapy; Near-infrared light; Surfactant; CANCER THERMOTHERAPY; THERAPEUTIC AGENT; NANOPARTICLES; DESTRUCTION; NANOTUBES; GUIDANCE;
D O I：
10.1007/s10103-013-1316-3
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Dimethyl sulfoxide porous silicon (DMSO-PSi) colloid in which DMSO was used as a surfactant suitable for inhibiting the agglomeration of PSi nanoparticles was prepared for use in cancer photothermotherapy. The photothermal effect of the DMSO-PSi colloid was found to be high enough to destroy cancer cells (T = similar to 52 A degrees C). The mean particle size of the PSi nanoparticles in the DMSO-PSi colloid was 67 nm, which is low enough to flow through blood vessels without causing a blockage. The DMSO-PSi colloid in combination with an NIR laser resulted in a cell viability of 5.70 %, which is a sufficiently high cytotoxic effect.
引用
收藏
页码：221 / 223
页数：3
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